Five Most Significant Publications prior to 2011 

Jin, C., K. McKeehan, W. Guo, S. Jauma, M. l. Ittmann, B. Foster, N. Greenberg, W. L. McKeehan, and F. Wang (2003) Cooperation between ectopic FGFR1 and depression of FGFR2 signaling in induction of high-grade prostatic intraepithelial neoplasia in mouse prostate. Cancer Res. 63: 8784-8790.

Lin Y, G. Liu, Y. Zhang, Y-P. Hu, K. Yu, C. Lin, K. McKeehan, J. W. Xuan, D. Ornitz, M. M. Shen, N. Greenberg, W. L. McKeehan, and F. Wang. (2007). Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and acquisition of strict androgen dependency for adult tissue homeostasis. Development 134: 723-734. (Feature of the Issue).

Zhang, Y., J. Zhang, Y. Lin, Y. Lan, C. Lin, J.W. Xuan, M.M. Shen, W.L. McKeehan, N.M. Greenberg, and F. Wang (2008).  Epithelial resident Fibroblast growth factor receptor substrate 2a-mediated signals in the prostate development, regeneration, and tumorigenesis. Development 135: 775-784 [Epub 2008 Jan 9].

Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin JF, Wang F.  (2008) Frs2{alpha}-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.  Development. 135:3611-3622 [EPub 2008 Oct 2].

Lin, Y., Chen, L., Lin, C., Luo, Y., Tsai, R.YL., and Wang, F. (2009) Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum. Dev Biol. 329:44-54 [EPub 2009 Feb 20].

Publications 2011

Xie, R, Nguyen, S, McKeehan, K, Wang, F, McKeehan, WL and Liu, L (2011) Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.  J. Biol. Chem. 286:10367-77 [EPub 2011 Jan 24].

Sims-Lucas S, Cusack B, Eswarakumar VP, Zhang J, Wang F, Bates CM (2011) Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium. Development [Epub 2011 Feb. 24] PMID 21350013.

Kobayashi, M, Huang, Y, Jin, C, Luo, Y, Okamoto, T, Wang, F and McKeehan, WL (2011) FGFR1 abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells. The Prostate doi: 10.1002/pros.21386. [Epub 2011 Mar 28]

Valiyeva F, Jiang F, Elmaadawi A, Moussa M, Yee SP, Raptis L, Izawa JI, Yang BB, Greenberg NM, Wang F, Xuan JW (2011) Characterization of the oncogenic activity of the novel TRIM59 gene in mouse cancer models. Mol Cancer Ther. 10(7):1229-40. [Epub 2011 May 18]

Jin, C, Yang, C, Wu, X, Wang, F and McKeehan, WL (2011) FGFR3-expressing smooth muscle-like stromal cells differentiate in response to FGFR2IIIb-expressing prostate tumor cells and delay tumor progression.  In Vitro Cell. Devel. Biol. 47:500-5 [Epub 2011 June 21]

Lin, X, Zhang, Y, Liu, L, McKeehan, WL, Shen, Y, Song, S and Wang, F (2011) FRS2a is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts. Int. J. Biol. Sci. 7(8):1114-21 [Epub 2011 Sep 15].

Yin Y, Wang F, Ornitz DM  (2011) Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development.  Development 138(15):3169-77.

Xie R, Wang F, McKeehan WL, Liu L (2011) Autophagy enhanced by microtubule and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis.  Cancer Res. 71:7537-46 [Epub 2011 Oct 28]

Wang F (2011) Modeling human prostate cancer in genetically engineered mice. Prog Mol Biol Transl Sci. 100:1-49. Review 

Publications 2012

Wang F, McKeehan WL, Shen MM, Abate-Shen C (2012) Genetically Engineered Mouse Models in Prostate Cancer Research. In: D J Tindall & PT Scardino, eds. Recent Advances in Prostate Cancer: Basic Science Discoveries and Clinical Advances, pp 219-282, World Scientific eBooks

Zhang J, Liu J, Huang Y, Chang JYF, Liu L, McKeehan WL, Martin JF, and Wang F (2012) FRS2a-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circulation Research 110(4):e29-39 [Epub 2011 Dec 29]

Yang X, Li Q, Lin X, Ma Y, Yue X, Tao Z, Wang F, McKeehan WL, Wei L, Schwartz RJ, Chang J. (2012) Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1. FASEB J. 26(5):2105-16 [EPub 2012 Jan 25]

Liu L, McKeehan WL, Wang F and Xie R (2012) MAP1S enhances autophagy to suppress tumorigenesis. Autophagy 8(2) [Epub 2012 Feb 1]

Zhang J, Liu J, Liu L, McKeehan WL, Wang F (2012) The fibroblast growth factor signaling axis controls cardiac stem cell differentiation through regulating autophagy. Autophagy 8(4) [Epub 2012 Apr 1]

Yang C, Jin C, Wang F, McKeehan WL, Luo Y (2012) Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS ONE 7(3):e33870 [EPub 2012 Mar 19]

Klionsky DJ, …… Wang F, et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4): 445-544

Zhou J, Qin L, Tien JC, Gao L, Chen X, Wang F, Hsieh JT, Xu J. (2012) Nkx3.1 functions as a “para-transcription factor” to regulate gene expression and cell proliferation in a non-cell-autonomous Manner. J. Biol. Chem. 287(21):17248-56 [Epub 2012 Mar 31] PMID: 22465996

Yang C, Wang C, Ye M, Jin C, He W, Wang F, McKeehan WL, Luo Y.  (2012) Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress.  Nutr Metab (Lond). Nutr Metab (Lond). 9(1):94 [Epub 2012 Oct 30]

Foltz IN, Hu S, King C, Wu X, Yang C, Wang W, Weiszmann J, Stevens J, Chen JS, Nuanmanee N, Gupte J, Komorowski R, Sekirov L, Hager T, Arora T, Ge H, Baribault H, Wang F, Sheng J, Karow JM, Wang M, Luo Y, McKeehan W, Wang Z, Véniant MM, Li Y. (2012) Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.  Sci Transl Med 4, 162ra153

Madakashira, B. P, D. A. Kobrinski, A. D. Hancher, E. C. Arneman, B. D. Wagner, F. Wang, H. Shin, F. J. Lovicu, L. W. Reneker, and M. L. Robinson (2012) FRS2a enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development. 139: 4601-4612 [Epub 2012 Nov 7] PMID: 23136392.

Shi, Z., Z. Cai, J. Yu, T. Zhang, S. Zhao, E. Smeds, Q. Zhang, F. Wang, C. Zhao, S. Fu, S. Ghosh, D. Zhang. (2012) TLR11 Prevents Salmonella's penetration into the murine Peyer's Patches. J. Biol. Chem. 287:43417-43423 [Epub 2012 Nov 7] PMID: 23135279

Chen, P.Y., L. Qin, C. Barnes, K. Charisse, T. Yi, X. Zhang, R. Ali, P.P. Medina, J. Yu, F.J. Slack, D.G. Anderson, V. Kotelianski, F. Wang, G. Tellides, M. Simons (2012). FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 27:1684-1696 [Epub 2012 Nov 29] PMID: 23200853. PMCID: PMC3534912

Publications 2013

Wang, J.J., Z.X. Fang, H.M. Ye, P. You, M.J. Cai, H.B. Duan, F. Wang, and Z.Y. Zhang (2013) Clinical significance of overexpressed cyclin-dependent kinase subunits 1 and 2 in esophageal carcinoma.  Dis Esophagus. [Epub 2013 Jan 10] PMID: 23301842

Zhang, T., J. Liu, J. Zhang, E. B. Thekkethottiyil, T. L. Macatee, F.A. Ismat, F. Wang, J. Z. Stoller (2013) Jun is Required in Isl1-expressing Progenitor 1 Cells for Cardiovascular Development. PloS ONE. 8(2): e57032. doi:10.1371/journal.pone.0057032 [Epub 2013 Feb 21]

Yang, F., Y. Zhang., S.J Ressler., M.M. Ittmann, G.E. Ayala, T.D. Dang, F. Wang, D.R. Rowley (2013) FGFR1 is essential for prostate cancer progression and metastasis. Can Res. [Epub 2013 Apr 10] PMID: 23576558

Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y. (2013) Activation of liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol.13(1):67. [Epub 17 Apr 2013]

Cai, Z., C. Tao, R. Ladher, N. Gotoh, G.-S. Feng, F. Wang, X. Zhang (2013) Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development (in press)