Five Most Significant Publications prior to 2008 

Jin, C., K. McKeehan, and F. Wang (2003) Transgenic mouse with high Cre recombinase activity in all prostate lobes, seminal vesicle, and ductus deferens. The Prostate 57:160-164.

Jin, C., K. McKeehan, W. Guo, S. Jauma, M. l. Ittmann, B. Foster, N. Greenberg, W. L. McKeehan, and F. Wang (2003) Cooperation between ectopic FGFR1 and depression of FGFR2 signaling in induction of high-grade prostatic intraepithelial neoplasia in mouse prostate. Cancer Res. 63: 8784-8790.

Zhang, Y., Y. Lin, Courtney Bowles, and F. Wang (2004). Direct cell cycle regulation by the FGFR kinase through phosphorylation-dependent release of Cks1 from FRS2. J. Biol. Chem. 279:  55348-55354.

Lin Y, G. Liu, Y. Zhang, Y-P. Hu, K. Yu, C. Lin, K. McKeehan, J. W. Xuan, D. Ornitz, M. M. Shen, N. Greenberg, W. L. McKeehan, and F. Wang. (2007). Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and acquisition of strict androgen dependency for adult tissue homeostasis. Development 134: 723-734. (Feature of the Issue).

Zhang, Y., K. McKeehan, Y. Lin, J. Zhang, and F. Wang (2007). FGFR1 tyrosine phosphorylation regulates binding of FRS2alpha but not FRS2beta to the receptor.  Mol. Endo. 22:167-175

Publications 2008

Zhang, Y., J. Zhang, Y. Lin, Y. Lan, C. Lin, J.W. Xuan, M.M. Shen, W.L. McKeehan, N.M. Greenberg, and F. Wang (2008).  Epithelial resident Fibroblast growth factor receptor substrate 2a-mediated signals in the prostate development, regeneration, and tumorigenesis. Development 135: 775-784 [Epub 2008 Jan 9].

Zhang, Y., K. McKeehan, Y. Lin, J. Zhang, and F. Wang (2008) FGFR1 tyrosine phosphorylation regulates binding of FRS2alpha but not FRS2beta to the receptor.  Mol. Endo. 22:167-175 [Epub 2007 Sep 27].

Lan, Y., Y. Zhang, C. Lin, M. Ittmann, and F. Wang (2008) Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting cell death, respectively.  International J. of Cancer 123: 543-551.

Sutherland, B.W., S.E. Knoblaugh, P.J. Kaplan-Lefko, F. Wang, M. Holzenberger, and N.M. Greenberg (2008) Conditional deletion of insulin-like growth factor-1 receptor in prostate epithelium. Cancer Res. 68:3495-3504.

Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin JF, Wang F.  Frs2{alpha}-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.  Development. 135:3611-3622 [EPub 2008 Oct 2].

Lin, Y., Y-S L. Cheng, C. Qin, C. Lin, R. D’Souza, and F. Wang, (2008) FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors.  Dev. Dyn 238:324-330. 

Publications 2009

Sims-Lucas S., V, Eswarakumar, D. Hains, K. Kish, B. Becknell, J. Zhang, F. Wang, and C. Bates (2009)  Deletion of Frs2α from the ureteric epithelium causes renal hypoplasia.  Am. J. Physiol. Renal Physiol., 297(5):F1208-1219. [Epub ahead of print] PMID: 19741018

Cai, Z., Z. Shi, A. Sanchez, T. Zhang, M. Liu, J. Yang, F. Wang, and D. Zhang (2009). Transcriptional regulation of TLR11 gene expression in epithelial cells. J. Biol. Chem. 284(48):33088-33096 [Epub ahead of print Oct. 2, 2009], PMID:19801549,

Huang, X.,  C. Yang, C. Jin, Y. Luo, F. Wang and W.L. McKeehan (2009) Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis. Mol. Carcinog.  48: 553-562 [Epub 2008 Nov. 13] 

Lin, Y., Y-S L. Cheng, C. Qin, C. Lin, R. D'Souza, and F. Wang, (2009) FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors.  Dev. Dyn.  238:324-330.

Lin, Y., Chen, L., Lin, C., Luo, Y., Tsai, R.YL., and Wang, F. (2009) Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum. Dev Biol. 329:44-54 [EPub 2009 Feb 20].

Luo, Y., Yang, C., Jin, C., Wang, F. and McKeehan, W.L. (2009) Novel phosphotyrosine targets of FGFR2IIIb signaling. Cellular Signalling 21: 1379-1378 [Epub 2009 May 4].

Xuan, J.W., Bygrave, M., Valiyeva, F., Moussa, M., Izawa, J.I., Bauman, G., Klibanov, A., Wang, F., Greenberg, N.M., and A. Fenster (2009) Molecular targeted enhanced ultrasound imaging of Flk1 reveals diagnosis and prognosis potential in genetically engineered mouse prostate cancer model.   Molecular Imaging.  8:209-220.

Sims-Lucas, S., Eswarakumar, V., Hains, D., Kish, K., Becknell, B., Zhang, J., Wang, F. and C. Bates (2009)  Deletion of Frs2α from the ureteric epithelium causes renal hypoplasia.  Am. J. Physiol. Renal Physiol. [Epub 2009 Sep 9]

Cai, Z., Shi, Z., Sanchez, A., Zhang, T., Liu, M., Yang, J., Wang, F. and D. Zhang (2009) Transcriptional regulation of TLR11 gene expression in epithelial cells. J. Biol. Chem. [Epub 2009 Oct 2].

McKeehan, W.L., Wang, F. and Luo, Y (2009)  The fibroblast growth factor (FGF) signaling complex.  In: R. A. Bradshaw and E. A. Dennis, eds., Handbook of Cell Signaling 2nd Edition, Oxford Academic Press, Vol. I, Ch. 38: 253-259. 

Publications 2010

Haling, J.R., F. Wang, and M. H. Ginsberg (2010)  Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha. Mol Biol Cell. 21: 664-673. [Epub 2009 Dec 23] PMID: 20032303

Shen, D.Y., Z.X. Fang, P. You, P.G. Liu, F. Wang, C.L. Huang, X.B. Yao, Z.X. Chen, Z.Y. Zhang (2010) Clinical significance and expression of Cks1 and Cks2 in hepatocellular carcinoma.  Liver International. 30: 119-125. PMID 19845855

Luo Y, Yang C, Lu W, Xie R, Jin C, Huang P, Wang F, McKeehan WL (2010) Metabolic regulator βklotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation [Epub 2010 July 23].