Five Most Significant Publications Prior to 2010

Liu, M., Chen, T.-Y., Ahamed, B., Li, J. and Yau, K.-Y.  1994.  Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel.   Science   266, 1348-1354. (Research Article)

Liu, M., and Simon, M.I.  1996.  Regulation by cAMP-dependent protein kinase of a G-protein mediated phospholipase C.   Nature   382, 82-87 (1996).

Stafford, L.J., Xia, C., Ma, W., Cai, Y., and Liu, M. (2002) Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein coupled receptor. Cancer Res.62: 5399-5404.

Hsu, Y-C., Chern, J.J., Cai, Y., Liu, M., and Choi, K.W. (2007) Drosophila homolog of TCTP regulates cell growth and proliferation through regulation of dRheb GTPase. Nature 445 (7129), 785-788.

Weng, J., Cheng, X., Luo, J., Jin, C., Zhou, X., Qu, J., Tong, L., Ai, D., Li, D., Wang, J., Amendt, B., Martin, J.F., and Liu, M. 2008. Deletion of G-protein coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down regulation of Pitx2. Proc. Natl. Acad. Sci. 105, 6081-6086.

Publications 2010

Yi, T., Tan, K., Cho, S.G., Wang, Y., Luo, J., Zhang, W., Li, D., and Liu, M.   2010.  Regulation of embryonic kidney branching morphogenesis and development by Gpr54 (KiSS1 receptor) through NFAT2 and Sp1 mediated Bmp7 expression.  J. Biol. Chemistry 285(23):17811-20. PMID: 20375015.  Evaluated by Faculty of 1000 Biology at http://f1000biology.com/article/id/3419956/evaluation

Dong Y, Lu B, Zhang X, Zhang J, Lai L, Li D, Wu Y, Song Y, Luo J, Pang X, Yi Z, and Liu M.  2010.  Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway.  Carcinogenesis. 2010 Dec; 31(12):2097-104. Epub 2010 Aug 23.  PMID: 20732905

Yadav VR, Sung B, Prasad S, Kannappan R, Cho SG, Liu M, Chaturvedi MM, and Aggarwal BB.  2010.  Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.  J Mol Med. 2010 Dec; 88(12):1243-53. Epub 2010 Aug 27.  PMID: 20798912

Wang J, Jia M, Zhu L, Yuan Z, Li P, Chang C, Luo J, Liu M, Shi T.   Systematical detection of significant genes in microarray data by incorporating gene interaction relationship in biological systems.  PLoS One. 2010 Oct 29; 5(10):e13721.  PMID: 21060778

Han H, Du B, Pan X, Liu J, Zhao Q, Lian X, Qian M, and Liu M.  CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation.  Mol Cancer Res. 2010 Nov; 8(11):1477-88. Epub 2010 Oct 6.  PMID: 21047770

Wang, Z., Jin, C., Li, H., Li, C., Hou, Q., Liu, M., Dong, X.D., and Tu, L.  2010.  GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation.   FEBS Lett. 584(18):4057-62. Epub 2010 Aug 21. PMID: 20732323

Zhang, Y., Jiang, X., Qin, X., Ye, D., Yi, Z., Liu, M., Bai, O., Liu, W., Xie, X., Wang, Z., Fang, J., and Chen, Y.  2010.  RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma.  Oncogene. 2010 Jul 5. [Epub ahead of print]PMID: 20603618

Li C, Yang Z, Li Z, Ma Y, Zhang L, Zheng C, Qiu W, Wu X, Wang X, Li H, Tang J, Qian M, Li D, Wang P, Luo J,  and Liu, M.  2010.  Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-kappaB and MAPK signaling pathways. J Bone Miner Res 2010 Sep 2. [Epub ahead of print]  PMID: 20814972

Xu, Y., Zuo, Y., Zhang, H., Kang, X., Yue, F., Yi, Z., Liu, M., Yeh, E.T.H., Chen, G., and Cheng, J.  2010.  Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis.   J. Biol. Chem.  285(47):36682-8. PMID: 20841360

Yang, Z., Li, C., Wang, X., Zhai, C., Yi, Z., Wang, L., Liu, B., Du, B., Wu, H., Guo, X., Liu, M., Li, D., and Luo, J.  2010.  Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells.  J Cell Physiol. 225(1):266-75. PMID: 20509140

Pang X, Zhang L, Wu Y, Lin L, Li J, Qu W, Safe S, and Liu, M.  Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor.  J Pharmacol Exp Ther. 2010 Oct; 335(1):172-9. Epub 2010 Jul 14.  PMID: 20631299

Li, C., Qiu, W., Yang, Z., Luo, J., Yang, F., Liu, M., Xie, J., and Tang, J.  2010.  Stereoselective synthesis of some methyl-substituted steroid hormones and their cytotoxic activity in vitro against human gastric cancer cell line MGC-803.  Steroids. 75(12):859-69. PMID: 20493894

Pang, X., Yi, Z.F., Zhang, J., Lu, B., Sung, B., Qu, W., Aggarwal, B.B., and Liu, M.  2010.  Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway.  Cancer Research 70(5):1951-9.  PMID: 20167862

Li C, Yang Z, Zhai C, Qiu W, Li D, Yi Z, Wang L, Tang J, Qian M, Luo J, and Liu M.  2010.  Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway.  Mol Cancer.  9(1):73. PMID: 20367887  (Highly Accessed Article)

Humtsoe, J.O., Liu, M., Malik, A.B., and Wary, K.K.  2010.  Lipid Phosphate Phosphatase-3 (LPP3) Stabilization of {beta}-catenin Induces Endothelial Cell Migration and Formation of Branching Point Structures.  Mol Cell Biol. 30(7):1593-606.   PMID: 20123964

Wang, L., Kuang, L., Pan, X., Liu, J., Wang, Q., Du, B., Li, D., Luo, J., Liu, M., Hou, A., and Qian, M.  2010.  Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1.  Int J Cancer. 127(5):1220-9. PMID: 20017136

Li, X.Y., Lu, Y., Sun, H.Y., Wang, J.Q., Yang, J., Zhang, H.J., Fan, N.G., Xu, J., Jiang, J.J., Liu, R.Y,, Li, D.L,., Liu, M.Y., and Ning, G.  2010.  G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract.  Development 137(1):151-7. PMID: 2002317 

Publications 2011 

Cho, S.G., Wang, Y., Rodriguez, M., Tan, K., Li, D., and Liu, M.*  2011.  Kiss1 G protein-coupled receptor (Gpr54) haploinsufficiency delays breast tumor initiation, progression and lung metastasis. Cancer Research 2011 Oct 15; 71(20)6535-46.  Epub 2011 August 18.  PMID: 21852382. (Cover story)

Pang, X., Zhang, L., Lai, L., Chen, J., Yi, Z., Zhang, J., Qu, W., Aggarwal, B.B., and Liu, M.* 2011.  1’-Acetoxychavicol Acetate Suppresses Angiogenesis- Mediated Human Prostate Tumor Growth by Targeting VEGF-mediated Src-FAK Signaling Pathway.  Carcinogenesis. 2011 Jun; 32(6):904-12. Epub 2011 Mar 22. PMID: 21427164.

Pang, X., Chen, J., Wang, J., Lu, B., Wu, Y., Yi, Z., Qu, W., and Liu, M.*  2011.  Gossypol, a Natural BH3 Mimetic, Suppresses Prostate Tumor Growth by Inhibiting VEGF Receptor 2-Mediated Angiogenesis. Molecular Cancer Therapeutics. 2011 Mar 3. PMID: 21372225.

Mitchell DC, Bryan BA, Liu L, Hu XH, Huang XQ, Ji WK, Chen PC, Hu WF, Liu JP, Zhang J, Liu M, Li DW.  2011.  GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism. Curr Mol Med. 2011 Aug; 11(6):465-80. IF= 5.212

Dong A, Fang Y, Zhang L, Xie J, Wu X, Zhang L, Lian X, Chen Y, Luo J, Liu M.* 2011. Caffeic acid 3,4-dihydroxy-phenethyl ester induces cancer cell senescence by suppressing twist expression.  J Pharmacol Exp Ther. 2011 Oct; 339(1):238-47. Epub 2011 Jul 15.  PMID: 21765040

Lai L, Liu J, Zhai D, Lin Q, He L, Dong Y, Zhang J, Lu B, Chen Y, Yi Z, Liu M.*  2011.  Plumbagin Inhibits Tumor Angiogenesis and Tumor Growth through VEGFR2-mediated Ras Signaling Pathway.  Br J Pharmacol. 2011 Jun 9. doi: 10.1111/j.1476-5381.2011.01532.x. [Epub ahead of print].  PMID: 21658027.

Pang X, Wu Y, Wu Y, Lu B, Chen J, Wang J, Yi Z, Qu W, Liu M.* 2011.  (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.  Mol Cancer Ther. 2011 May; 10(5):795-805. Epub 2011 Mar 3. PMID: 21372226

Yu W, Qiu Z, Gao N, Wang L, Cui H, Qian Y, Jiang L, Luo J, Yi Z, Lu H, Li D, and Liu M.* 2011. PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop. Nucleic Acids Res. 2011 Mar; 39(6):2234-48. Epub 2010 Nov 21. PMID: 21097889

Cai Z, Sanchez A, Shi Z, Zhang T, Liu M, Zhang D.  2011.  Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth. Cancer Research 2011 Apr 1; 71(7):2466-75. Epub 2011 Mar 22.PMID:21427357.

Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X. 2011. Anacardic Acid (6-Pentadecylsalicylic Acid) Inhibits Tumor Angiogenesis by Targeting Src/FAK/Rho GTPases Signaling Pathway.  J Pharmacol Exp Ther. 2011 Nov; 339(2):403-11. Epub 2011 Aug 9.  PMID: 21828260

Zhang Z, Wang Z, Ren H, Yue M, Huang K, Gu H, Liu M, Du B, Qian M.  2011.  P2Y6 Agonist Uridine 5'-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte Chemoattractant Protein-1-Mediated Monocytes/ Macrophages Recruitment.  J. Immunol. 2011 Mar 28.PMID: 21444765

Kuang L, Wang L, Wang Q, Zhao Q, Du B, Li D, Luo J, Liu M, Hou A, Qian M.  2011. Cudratricusxanthone G inhibits human colorectal carcinoma cell invasion by MMP-2 down-regulation through suppressing activator protein-1 activity.  Biochem Pharmacol. 2011 Mar 4. PMID:21377450

Jia Y, Jing J, Bai Y, Li Z, Liu L, Luo J, Liu M, Chen H. Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-regulation of JAK-STAT and NF-<kappa>B Signaling Pathways. PLoS One. 2011; 6(10):e27006. Epub 2011 Oct 31. PMID： 22066025

Chen G, Yin K, Shi L, Fang Y, Qi Y, Li P, Luo J, He B, Liu M, Shi T. 2011. Comparative analysis of human protein-coding and noncoding RNAs between brain and 10 mixed cell lines by RNA-Seq.  PLoS One 2011; 6(11):e28318. Epub 2011 Nov 30. PMID: 22140575

Chen G, Li R, Shi L, Qi J, Hu P, Luo J, Liu M, Shi T.  2011.  Revealing the missing expressed genes beyond the human reference genome by RNA-Seq.  BMC Genomics 2011 Dec 2; 12(1):590.  PMID: 22133125

Chen L, Wu H, Pochynyuk OM, Reisenauer MR, Zhang Z, Huang L, Zaika OL, Mamenko M, Zhang W, Zhou Q, Liu M, Xia Y, Zhang W. 2011.  Af17 deficiency increases sodium excretion and decreases blood pressure.  J Am Soc Nephrol. 2011 Jun; 22(6):1076-86. Epub 2011 May 5.  PMID: 21546577.

Zhang X, Song Y, Wu Y, Dong Y, Lai L, Zhang J, Lu B, Dai F, He L, Liu M, Yi Z.  2011.  Indirubin inhibits tumor growth by anti-tumor angiogenesis through blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell. Int J   Cancer. 2011 Jan 4. [Epub ahead of print] PMID: 21207415

Yang J, Fan H, Hao J, Ren Y, Chen L, Li G, Xie R, Yang Y, Qian K, Liu M. 2011.  Amelioration of acute graft-versus-host disease by adoptive transfer of ex vivo expanded human cord blood CD4+CD25+ forkhead box protein 3+ regulatory T cells is associated with the polarization of Treg/Th17 balance in a mouse model.  Transfusion. 2011 Nov 21. doi: 10.1111/j.1537-2995.2011.03448.x. [Epub ahead of print].  PMID: 22098312

Teng Y, Liu M, Cowell JK.  2011.  Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells. Int J Cancer. 2011 Dec 15; 129(12):2825-35. doi: 10.1002/ijc.25964. Epub 2011 May 5. PMID: 21544801

Pan X, Han H, Wang L, Yang L, Li R, Li Z, Liu J, Zhao Q, Qian M, Liu M, Du B.  2011.  Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway. Cancer Lett. 2011 Dec 27; 313(2):181-91. Epub 2011 Sep 10.  PMID: 21959111

Sung B, Cho SG, Liu M, and Aggarwal BB.   2011.  Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of RANKL signaling.  Int J Cancer. 2010 Dec 17..PMID: 21170936

Park, B., Sung, B., Yadav, V., Cho, S.G., Liu, M., and Aggarwal, B.B. 2011.  Acetyl-11-keto-β-Boswellic Acid Suppresses Invasion of Pancreatic Cancer Cells through the Downregulation of CXCR4 Chemokine Receptor expression.  Int J Cancer 2011 Jul 1; 129(1):23-33. doi: 10.1002/ijc.25966. Epub 2011 Mar 29. PMID: 21448932

Chen J, Li T, Wu Y, He L, Zhang L, Shi T, Yi Z, Liu M, Pang X.  2011.  Prognostic significance of vascular endothelial growth factor expression in gastric carcinoma: a meta-analysis. J Cancer Res Clin Oncol. 2011 Dec; 137(12):1799-812. Epub 2011 Sep 15.  PMID: 21918901

He L, Wu Y, Lin L, Wang J, Wu Y, Chen Y, Yi Z, Liu M, and Pang X.   2011.  Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway. Cancer Sci. 2011 Jan; 102(1): 219-25.PMID: 21087351 

Publications 2012

Wang J, Li X, Ke Y, Lu Y, Wang F, Fan N, Sun H, Zhang H, Liu R, Yang J, Ye L, Liu M, Ning G.  2012.  GPR48 increases mineralocorticoid receptor gene expression.  J Am Soc Nephrol. 2012 Feb;23(2):281-93.  PMID: 22135314

Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, Yi Z, Chen Y, Pang X, Liu M. 2012.  Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer.  Mol Cancer Ther. 2012 Feb;11(2):277-87. Epub 2011 Dec 27.  PMID: 22203730

Xu J, Li Z, Luo J, Yang F, Liu T, Liu M, Qiu W, Tang J.  2012.  Synthesis and Biological Evaluation of Heterocyclic Ring-fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption.  J Med Chem. 2012 Mar 21. [Epub ahead of print] PMID: 22435650

Wang Y, Chen Y, Wang J, Chen J, Aggarwal BB, Pang X, Liu M.  2012.  Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor. Curr Mol Med. 2012 Feb; 12(2):153- 62. IF= 5.212

Tang XL, Wang Y, Li DL, Luo J, Liu MY. 2012.  Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.  Acta Pharmacol Sin. 2012 Mar;33(3):363-71. doi: 10.1038/aps.2011.210. Epub 2012 Feb 27.  PMID: 22367282 

Fan H, Yang J, Hao J, Ren Y, Chen L, Li G, Xie R, Yang Y, Gao F, Liu M. 2012.  Comparative Study of Regulatory T Cells Expanded Ex Vivo from Cord Blood and Adult Peripheral Blood.  Immunology. 2012 Feb 20. doi: 10.1111/j.1365-2567.2012.03573.x. [Epub ahead of print]  PMID: 22348606

Wu X, Li Z, Yang Z, Zheng C, Jing J, Chen Y, Ye X, Lian X, Qiu W, Yang F, Tang J, Xiao J, Liu M, Luo J. 2012.  CADPE suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of MAPK/AP-1 and Ca(2+) -NFAT signaling pathways.  J Bone Miner Res. 2012 Feb 15. doi: 10.1002/jbmr.1576. [Epub ahead of print]  PMID: 22337253.