2003 Bachelor of Medicine (M.D. Equivalent),
Zhejiang University, School of Medicine
2008 Ph.D. & M.S., Biochemistry, Georgia State University,
2009 Research Fellow, Immune Disease Institute,
Harvard Medical School, Boston, MA
Program in Cellular and Molecular Medicine at
Children’s Hospital Boston
2010 Research Fellow, La Jolla Institute for Allergy and
Immunology, La Jolla, CA
Imbalanced DNA methylation/demethylation results in abnormal gene expression and increased genome instability, which is frequently observed in human cancers. Dr. Huang ’s research interests are directed towards understanding how DNA methylation/demethylation balance is maintained in mammals and how aberrant DNA methylation and its oxidation products contribute to human cancer. Dr. Huang’s ongoing research includes using high-throughput sequencing to study the DNA modifications in human cancer, elucidating the role of DNA modification enzymes in mouse models, and exploring novel anti-cancer or preventive strategies by targeting key epigenetic pathways.
Dr. Huang has significantly contributed to the functional characterization of the ten eleven translocation (TET) enzymes in hematological malignancies. Dr. Huang also pioneered the use of innovative tools to probe the “sixth DNA base”, 5-hydroxymethylcytosine (5hmC), in the human genome and was among the first to profile the hydroxylmethylome in mouse embryonic stem cells. Her recent studies related to TET enzyme and 5hmC resulted in more than 15 peer-reviewed publications in top scientific journals and over 1,700 citations. She was recruited to the Texas A&M Health Science Center Institute of Biosciences & Technology as a CPRIT scholar in 2014.
1. Huang Y, Chavez L, Xing C, Wang X, Pastor WA, Kang J, Zepeda-Martínez J, Pape UJ, Jacobsen S, Peters B, Rao A. Distinct role of Tet1 and Tet2 in gene regulation and exon expression. PNAS. 2014 Jan 28;111(4):1361-6 (PMID: 24474761)
2. Huang Y, Pastor WA, Zepeda-Martinez A. J, Anjana Rao. The anti-CMS method for genome-wide mapping of 5- hydroxymethylcytosine. Nature Protocols. 2012 Oct, 7(10): 1909-17 (PMID: 23018194)
3. Pastor WA*, Pape UJ*, Huang Y*, Henderson HR, Lister R, Ko M, McLoughlin EM, Brudno Y, Mahapatra S, Kapranov P, Tahiliani M, Daley GQ, Liu XS, Ecker JR, Milos PM, Agarwa S, Anjana Rao A. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature. 2011 May, 473(7347):394-7 (*Co-first author)
4. Ko M*, Huang Y*, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, An J, Lamperti ED, Koh KP, Ganetzky R, Liu XS, Aravind L, Agarwal S, Maciejewski JP, Rao A. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010 Dec 9;468(7325):839-43. (* Co-first author; PMID: 21057493)
5. Huang Y, Pastor WA, Shen Y, Tahiliani M, Liu DR, Rao A. The behavior of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One. 2010 Jan 26:5(1):e8888.
6. Jeong M*, Sun D*, Luo M*, Huang Y#, Challen GA#, Rodriguez B, Zhang X, Chavez L, Ko M, Wang H, Chen R, Hannah R, Ki, SB, Lee JS, Gottgens B, Gunaratne P, Goddley LA, Darlington GJ, Rao A, Li W, Gooddell MA. Large conserved domains of low DNA methylation maintained by 5-hydroxymethylcytosine and Dnmt3a. Nature Genetics. 2014 Jan;46(1):17-23. (* # equal contribution, PMID: 24270360)
7. Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT. Stage-Specific Roles for Tet1 and Tet2 in DNA Demethylation in Primordial Germ Cells. Cell Stem Cell. 2013 Feb, 1934-5909(13)00019-2. (PMID: 23415914)