Arthur Laganowsky

Arthur Laganowsky

Assistant Professor

Center for Infectious and Inflammatory Diseases
2121 W. Holcombe Blvd.
Houston, TX   77030

Education and Training

2004     B.S., Biological Sciences, California State University,
               Chico, CA

2006     M.S., Biological Sciences, California State University,
               Chico, CA

2006-    Ph.D., Chemistry and Molecular Biology, University of  
2011     California, Los Angeles, California

2011-    Postdoc, Physical and Theoretical Chemistry,  
2014     University of Oxford, Oxford, UK

Research Interests

A long-term research goal of our group is to determine the molecular basis behind protein-lipid interactions and how these interactions can modulate the structure and function of membrane proteins, including their interactions with signaling molecules. What determines the selectivity of membrane proteins towards lipids, and the coupling between lipid binding events and function remains a key knowledge gap in the field; one that if addressed will significantly advance our understanding of how lipids participate in both normal and pathophysiological processes of membrane proteins. Therefore, there is a critical need to expand our fundamental knowledge in this emerging field by applying and developing innovative approaches to elucidate how lipids modulate the structure function of membrane proteins.  To this end, we are studying a number of ion channels, receptors and other types of membrane proteins.  Please visit my website for more information…

Recent Publications

1. Laganowsky A, Reading E, Allison TM, Ulmschneider MB, Degiacomi MT, Baldwin AJ, Robinson CV. Membrane proteins bind lipids selectively to modulate their structure and function. Nature 2014, in press. (Cover Article).

2. Laganowsky A, Reading E, Hopper J, Robinson CV. Mass spectrometry of intact membrane protein complexes. Nature Protocols 2013, 8:639-51 (Cover Article).

3. Laganowsky A, Lui C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga A, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science 2012.

4. Colletier J-P§, Laganowsky A§, Landau M, Zhao ML, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Molecular basis for amyloid-beta polymorphism. PNAS. 2011, 108(41): 16938-43. §Equal authorship.

5. Laganowsky A, Zhao M, Soriaga AB, Sawaya MR, Cascio D, Yeates TO. An approach to crystallizing proteins by metal-mediated synthetic symmetrization. Protein Science 2011, 20(11):1876-90. Ranked “must read” in Faculty of 1000.

6. Landau M, Sawaya MR, Faull KF, Laganowsky A, Jiang L, Sievers SA, Barrio JR, Eisenberg D. Towards a pharmacophore for amyloid. PLoS Biol 2011, 9(6): e1001080. doi:10.1371/journal.pbio.1001080.

7. Laganowsky A, Eisenberg D. Non-3D domain swapped crystal structure of truncated Zebrafish alphaA crystallin. Protein Science 2010, 19(10):1978-1984.

8. Laganowsky A, Benesch J LP, Landau M, Ding L, Sawaya M, Cascio D, Huang Q, Robinson CV, Horwitz J, Eisenberg D. Crystal structures of truncated AlphaA and AlphaB crystallin reveal structural mechanisms of polydispersity important for eye lens transparency. Protein Science 2010, 19(5):1031-43. (Cover Article). 

9. Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A. The structured core domain of B-crystallin can prevent amyloid fibrillation and associated toxicity. PNAS. 2014, 111(16): E1562-70.