Cheryl Lyn Walker

Cheryl Lyn Walker

Professor, Robert A. Welch Professor, Director

Center for Translational Cancer Research
2121 W. Holcombe Blvd.
Houston, TX   77030

Education and Training

1984   University of Texas Health Science Center, Southwestern Medical School, Dallas, TX, Ph.D. Cell Biology

1977   University of Colorado, Boulder, CO, BA, Molecular, Cell & Developmental Biology

1984-1988     Staff Fellow, National Institute of Environmental Health Science, Research Triangle Park, NC, Drs. Paul Nettesheim and J. Carl Barrett, Laboratory of Pulmonary Pathobiology

Awards and Honors

2012   Appointed to the Board of Scientific Advisors of the National Cancer Institute

2010   Fellow, Academy of Toxicological Sciences

    

2010   Cozzarelli Prize for Biological Sciences from the National Academy of Sciences

2009-10   Andrew Sowell-Wade Huggins Professorship and Graduate Fellowship in Cancer Research

2007   The LAM Foundation, Established Investigator Award

2006   The Dallas/Fort Worth Living Legend Faculty Achievement Award in Basic Research

2009-10   President, Society of Toxicology, Society of Toxicology

Recent Publications

Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol. doi: 10.1038/ncb3230. 9/2015. PMID: 26344566

Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, Zhou Y. Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx. Nat Cell Biol. doi: 10.1038/ncb3234. 8/2015. PMID: 26322679

Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Paige Lawrence B, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ. Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives. Endocrinology :EN20151350. 8/2015. PMID: 26241067

Ho TH, Park IY, Zhao H, Tong P, Champion MD, Yan H, Monzon FA, Hoang A, Tamboli P, Parker AS, Joseph RW, Qiao W, Dykema K, Tannir NM, Castle EP, Nunez-Nateras R, Teh BT, Wang J, Walker CL, Hung MC, Jonasch E. High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma. Oncogene. doi:10.1038/onc.2015.221. 6/2015. PMID: 26073078.

Treviño LS, Wang Q, Walker CL. Phosphorylation of epigenetic "readers, writers and erasers": Implications for developmental reprogramming and the epigenetic basis for health and disease. Prog Biophys Mol Biol. 118(1-2):8-13. 7/2015. PMID: 25841987.

Wong RL, Wang Q, Treviño LS, Bosland MC, Chen J, Medvedovic M, Prins GS, Kannan K, Ho SM, Walker CL. Identification of secretaglobin Scgb2a1 as a target for developmental reprogramming by BPA in the rat prostate. Epigenetics. 10(2):127-34. 1/2015. PMID: 25612011.

Sahin K, Cross B, Sahin N, Ciccone K, Suleiman S, Osunkoya AO, Master V, Harris W, Carthon B, Mohammad R, Bilir B, Wertz K, Moreno CS, Walker CL, Kucuk O. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Arch Biochem Biophys. 15;572:36-9. 4/2015. PMID: 25602702.

Treviño LS, Wang Q, Walker CL. Hypothesis: Activation of rapid signaling by environmental estrogens and epigenetic reprogramming in breast cancer. Reprod Toxicol. 54:136-40. 7/2015. PMID: 25554384.

Dere R, Perkins AL, Bawa-Khalfe T, Jonasch D, Walker CL. β-Catenin Links von Hippel-Lindau to Aurora Kinase A and Loss of Primary Cilia in Renal Cell Carcinoma. J Am Soc Nephrol. 26(3):553-564. 5/2015. PMID: 25313256.

Liu XD, Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, Zhang J, Bai S, German P, Hoang A, Zhou L, Jonasch D, Zhang X, Conti CJ, Efstathiou E, Tannir NM, Eissa NT, Mills GB, Walker CL, Jonasch E. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 34(19):2450-2460. 5/2015. PMID: 24998849.

Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 23;53(2):209-20. 1/2014. PMID: 24389102

Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Nardo AD, Han JM, Kwiatkowski E, Dunlop EA, Dodd KM, Folkerth RD, Faust PL, Kastan MB, Sahin M, Walker CL. A TSC signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol. 15(10):1186-1196, 10/2013. PMID: 23955302.

* Highlighted as “featured article” on Nature Review Molecular Cell Biology:
R. David, Cell signaling: A peroxisomal home for TSC, Nature Reviews Molecular Cell Biology 2013, 14, 609. (http://www.nature.com/nrm/journal/v14/n10/full/nrm3661.html).
 
* Highlighted in Nature Cell Biology “News and Views”:
D. Benjamin, M. N. Hall, TSC on the peroxisome controls mTORC1. Nature CellBiololgy. 2013 15, 1135–1136. (http://www.nature.com/ncb/journal/v15/n10/full/ncb2849.html).
 
* Highlighted in Science Signaling “Editors’ choice”:
N. R. Gough,Inhibiting mTORC1 at the Peroxisome. Science Signaling 2013, 6, ec250 (http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/297/ec250)
 
* Rated as “Must Read” on Faculty 1000: (http://f1000.com/prime/718077575)


Tripathi DN, Chowdhury R, Trudel LJ, Tee AR, Slack RS, Walker CL, Wogan GN. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A. 110(32):E2950-E2957, 8/2013. PMID: 23878245.

Wong RL, Walker CL. Molecular pathways: environmental estrogens activate nongenomic signaling to developmentally reprogram the epigenome. Clin Cancer Res. 19(14):3732-37. 07/2013. PMID: 23549878

Walker CL, Ho SM. Developmental reprogramming of cancer susceptibility. Nat Rev Cancer. 12(7):479-86, 6/2012. PMID: 22695395.

Alexander A, Walker CL. Differential localization of ATM is correlated with activation of distinct downstream signaling pathways. Cell Cycle 9(18):3685-6, 9/2010. e-Pub 9/5/2010. PMID: 20890104.

Alexander A, Kim J, Walker CL. ATM engages the TSC2/mTORC1 signaling node to regulate autophagy. Autophagy 6(5). e-Pub 7/28/2010. PMID: 20581436.

McCampbell AS, Broaddus RR, Walker CL. Loss of inhibitory insulin receptor substrate-1 phosphorylation: An early event in endometrial hyperplasia and progression to carcinoma. Cell Cycle 9(14):2698-9, 7/15/2010. e-Pub 7/9/2010. PMID: 20676044.

Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol 24(5):993-1006, 5/2010. e-Pub 3/29/2010. PMCID: PMC2870935.

Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 107(9):4153-8, 3/2/2010. e-Pub 2/16/2010. PMCID: PMC2840158.

McCampbell AS, Harris HA, Crabtree JS, Winneker RC, Walker CL, Broaddus RR. Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma. Cancer Prev Res (Phila) 3(3):290-300, 3/2010. e-Pub 2/23/2010. PMID: 20179297.

Dere R, Wilson PD, Sandford RN, Walker CL. Carboxy Terminal Tail of Polycystin-1 Regulates Localization of TSC2 to Repress mTOR. PLoS One 5(2):e9239, 2010. e-Pub 2/16/2010. PMCID: PMC2821926.

Crabtree JS, Jelinsky SA, Harris HA, Choe SE, Cotreau MM, Kimberland ML, Wilson E, Saraf KA, Liu W, McCampbell AS, Dave B, Broaddus RR, Brown EL, Kao W, Skotnicki JS, Abou-Gharbia M, Winneker RC, Walker CL. Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of rapamycin pathway. Cancer Res 69(15). e-Pub 7/21/2009. PMID: 19622772.

Yu J, Robb VA, Morrison TA, Ariazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer LF, Nicholas E, Hensley H, Jordan VC, Walker CL, Henske EP. Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Proc Natl Acad Sci U S A 106(8):2635-40, 2/2009. e-Pub 2/2009. PMCID: PMC2637277.

Kim J, Jonasch E, Alexander A, Short JD, Cai S, Wen S, Tsavachidou D, Tamboli P, Czerniak BA, Do KA, Wu KJ, Marlow LA, Wood CG, Copland JA and Walker CL. Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma. Clin Cancer Res 15(1):81-90, 1/2009. NIHMSID: NIHMS118521.

Greathouse KL, Cook JD, Lin K, Davis BJ, Berry TD, Bredfeldt TG, Walker CL. Identification of uterine leiomyoma genes developmentally reprogrammed by neonatal exposure to diethylstilbestrol. Reprod Sci 15(8):765-78, 10/2008. PMID: 19017814.

Short JD, Houston KD, Dere R, Cai SL, Kim J, Johnson CL, Broaddus RR, Shen J, Miyamoto S, Tamanoi F, Kwiatkowski D, Mills GB, Walker CL. AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Res 68(16):6496-506, 8/2008. PMID: 18701472.

Laping NJ, Everitt JI, Frazier KS, Burgert M, Portis MJ, Cadacio C, Gold LI, Walker CL. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin Cancer Res 13(10):3087-99, 5/2007. PMID: 17505012.

Cook JD, Davis BJ, Goewey JA, Berry TD, Walker CL. Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in eker rats. Reprod Sci 14(2):121-36, 2/2007. PMID: 17636224.

Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9(2):218-24, 2/2007. PMID: 17237771.

Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol 173(2):279-89, 4/2006. PMCID: PMC2063818.

Cook JD, Davis BJ, Cai SL, Barrett JC, Conti CJ, Walker CL. Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance. Proc Natl Acad Sci U S A 102(24):8644-9, 6/2005. PMCID: PMC1150843.

Walker CL, Stewart EA. Uterine fibroids: the elephant in the room. Science 308(5728):1589-92, 6/2005. PMID: 15947177.

Cai S, Everitt JI, Kugo H, Cook J, Kleymenova E, Walker CL. Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development. Am J Pathol 162(2):457-68, 2/2003. PMCID: PMC1851170.

Liu MY, Cai S, Espejo A, Bedford MT, Walker CL. 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). Cancer Res 62(22):6475-80, 11/2002. PMID: 12438239.

Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri RA, Jr, Krymskaya VP. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem 277(34):30958-67, 8/2002. PMID: 12045200.

Hunter DS, Klotzbucher M, Kugoh H, Cai SL, Mullen JP, Manfioletti G, Fuhrman U, Walker CL. Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function. Cancer Res 62(13):3766-72, 7/2002. PMID: 12097287.

Kleymenova E, Ibraghimov-Beskrovnaya O, Kugoh H, Everitt J, Xu H, Kiguchi K, Landes G, Harris P, Walker C. Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Mol Cell 7(4):823-32, 4/2001. PMID: 11336705.

Walker CL, Burroughs KD, Davis B, Sowell K, Everitt JI, Fuchs-Young R. Preclinical evidence for therapeutic efficacy of selective estrogen receptor modulators for uterine leiomyoma. J Soc Gynecol Investig 7(4):249-56, 8/2000. PMID: 10964025.

Hunter DS, Hodges LC, Vonier PM, Fuchs-Young R, Gottardis MM, Walker CL. Estrogen receptor activation via activation function 2 predicts agonism of xenoestrogens in normal and neoplastic cells of the uterine myometrium. Cancer Res 59(13):3090-9, 7/1999. PMID: 10397250.

Rennebeck G, Kleymenova EV, Anderson R, Yeung RS, Artzt K, Walker CL. Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development. Proc Natl Acad Sci U S A 95(26):15629-34, 12/1998. PMCID: PMC28095.

Everitt JI, Walker CL, Goldsworthy TW, Wolf DC. Altered expression of transforming growth factor-alpha: an early event in renal cell carcinoma development. Mol Carcinog 19(3):213-9, 7/1997. PMID: 9254888.

Burroughs KD, Kiguchi K, Howe SR, Fuchs-Young R, Trono D, Barrett JC, Walker C. Regulation of apoptosis in uterine leiomyomata. Endocrinology 138(7):3056-64, 7/1997. PMID: 9202252.

Quelle D, Ashmun RA, Hannon GJ, Rehberger PA, Trono D, Richter KH, Walker C, Beach D, Sherr CJ, Serrano M. Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene 11(4):635-45, 8/1995. PMID: 7651726.

Everitt JI, Wolf DC, Howe SR, Goldsworthy TL, Walker C. Rodent model of reproductive tract leiomyomata. Clinical and pathological features. Am J Pathol 146(6):1556-67, 6/1995. PMCID: PMC1870902.

Howe SR, Gottardis MM, Everitt JI, Walker C. Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo. Endocrinology 136(11):4996-5003, 1995. PMID: 7588234.

Everitt JI, Goldsworthy TL, Wolf DC, Walker CL. Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome. J Urol 148(6):1932-6, 12/1992. PMID: 1433648.

Walker C, Goldsworthy TL, Wolf DC, Everitt J. Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene. Science 255(5052):1693-5, 3/1992. PMID: 1553556.