Sponsors
Stephen Safe (Principal Investigator)
The major sponsors of Dr. Safe's research include the National Institutes of Health, DOD - Army Breast Cancer Research Program, American Chemistry Council and a list of current grant support is given below.
NIEHS; P42 ES04917 (Superfund) 04/01/00 - 03/31/05
"Procedures to Assess the Hazard of a Superfund Site"
The major aims of this project include (i) synthesis of analytical and toxicological standards; (ii) development of in vitro bioassays (P4501A1 induction, antiestrogenicity, DRE binding); (iii) in vivo bioassays to determine TEFs for polynuclear and halogenated aromatic hydrocarbons; and (iv) application of TEFs for site extract risk assessment.
CEGM collaborators: R. H. Finnell, K.C. Donnelly
NIEHS; R01-ES04176 01/01/02 - 12/31/07
"Effects of 2,3,7,8-TCDD on Estrogenic Responses"
This project is focused on the molecular biology of TCDD-induced antiestrogenicity in MCF-7 cells and utilizes 5'-regulatory sequences from diverse estrogen-regulated genes to identify cis-acting genomic sequences and trans-acting factors. The role of DRE and DRE-Sp1 motifs as enhancer sequences in the cathepsin D gene will also be investigated.
NIEHS; T32-ES07273 07/01/02 - 06/30/07
"Toxicology of Environmental Contaminants"
This is a toxicology training grant proposal supporting six graduate research assistants and one postdoctoral fellow. S. Safe is the PI on this proposal, and there are nine co-PIs. Support is for two graduate assistantships.
CEGM collaborators: R. H. Finnell, K.C. Donnelly
NIEHS; P30-ES09106 04/01/02 - 03/31/07
"Center for Environmental and Rural Health"
The major aims of this proposal are to provide core facilities for Center investigators who will focus on research problems associated with rural and environmental health. (No direct funds for S. Safe.)
CEGM collaborators: R. H. Finnell, K.C. Donnelly
DOD-US Army MRMC 11/01/01 - 12/31/04
"Inhibitory Ah Receptor-Androgen Receptor Crosstalk in Prostate Cancer"
This project will investigate the mechanisms of inhibitory AhR-AR interactions in prostate cancer and will determine if inhibitory AhR-AR crosstalk blocks androgen-induced cell cycle progression.
NIEHS; R01-ES09253 (Safe) 02/06/02 - 01/31/07
"Mechanisms of Growth Factor-Estrogen Receptor Crosstalk"
The major aims of this project are to define molecular mechanisms of growth factor-estrogen receptor crosstalk associated with induction of cathepsin D and c-fos expression in breast cancer cells. The mechanism of inhibition of growth factor-induced responses by TCDD will also be investigated.
Richard Finnell (Principal Investigator)
Centers for Disease Control (U59/CCU913241) (10/02-9/07)
Genetic and Environmental Risks of Common Birth Defects, Dr. Gary Shaw, PI.
CEGM collaborators: R. H. Finnell, K.C. Donnelly
Centers for Disease Control (U50/CCU613232) (10/02-9/07)
National Birth Defects Prevention Study-Texas, Dr. Mark Canfield, PI.
CEGM collaborators: R. H. Finnell, K.C. Donnelly
National Institutes of Health (RO1 DE13613) (4/99-3/04)
Folate receptors and craniofacial defects
NIEHS Superfund Basic Research Program
Dr. Stephen Safe, PI
CEGM Collaborators: R. H. Finnell
National Institutes of Health/US EPA (Grant No. 82829201) (1/01-12/06)
Gene Environment Interaction and Human Malformations, Dr. Gary Shaw, PI
CEGM Collaborators: R. H. Finnell
National Institutes of Dental Research
Folate pathway genes and risk for orofacial clefts, Dr. Hary Shaw, PI
CEGM Collaborators: R. H. Finnell
March of Dimes (6/01-5/03)
Folic Acid Deficiency and the Induction of NTDs.
National Institutes of Health, (HL66398) (9/01-8/06)
Folic Acid and Homocysteine: Mechanisms of Heart Defects, Dr. Thomas H. Rosenquist, PI
Richard Finnell Co-Director.
National Institutes of Health
Arsenic Embryopathy:Cellular and Molecular Targets, M. Pisano, PI
CEGM Collaborators: R. Finnell
Environmental Protection Agency
Evaluation of Models for Exposure Assessment in Humans, D.C. Donnelly, PI
CEGM Collaborators: R. Finnell
Laura Mitchell (Principal Investigator)
Grants - Funded
Title: Maternal and embyronic causes of spina bifida
Agency: NIH (R01 HD39195)
Annual direct: $470,000
Dates: 04/01/06-02/28/11
Role: PI
Title: Gene nutrient etiologies of human heart defects
Agency: NIH (R01HL085859)
Annual direct:
Dates: 10/1/06-9/30/09
Role: Investigator
Title: Procedures to assess the hazards of a Superfund site
Agency: NIH (P42 ES004917)
Annual direct: $1,000,000
Dates: 04/01/05-03/31/10
Role: Project PI, Environmental determinants of neural tube defects
Title: Gene-nutrient etiologies of neural tube defects
Agency: NIH (R01 NS050249)
Direct/Indirect: $200,000
Dates: 09/01/05-08/31/10
Role: Co-investigator
Title: Genetic regulation of folate responsive birth defects
Agency: NIH (R01 DE016135)
Annual direct: $345,000
Dates: 08/01/05-04/30/10
Role: Co-investigator
Title: Genetic etiology of conotruncal heart malformations
Agency: NIH (R01 HL076773)
Annual direct: $200,000
Dates: 04/01/04-03/31/09
Role: Co-investigator and subcontract PI
Title: SCCOR in genetic mechanisms of pediatric heart disease
Agency: NIH (P60 HL74731)
Annual direct: $2,600,000
Dates: 01/01/04-12/31/09
Role: Co-investigator and subcontract PI
Title: Genetic etiology of left sided cardiac defects
Agency: NIH (R01 HL074094)
Annual direct: $330,000
Dates: 09/01/03-08/31/08
Role: Co-investigator and subcontract PI
Title: Pharmacogenetics of methotrexate therapy in arthritis
Agency: NIH (R01 AR47663)
Annual direct: $386,000
Dates: 09/01/02-08/31/07 (in no cost extension)
Role: Co-investigator and subcontract PI
Grants - Pending
Title: Procedures to Assess the Hazards of a Superfund Site (competitive renewal)
Project 5: Environmental Determinants of Neural Tube Defects
Agency: NIH (Overall score: 230, Project 5 Score: 169)
Annual direct: $1,000,000
Dates: 04/01/05-03/31/10
Role: Project 5 PI
Title: Maternal and embryonic causes of spina bifida (Supplement to funded R01)
Agency: NIH (Percentile: 2.6)
Annual direct: $126,000
Dates: 3/1/08-2/28/11
Role: PI
Title: Spina bifida candidate genes and regions (new R01)
Agency: NIH
Annual direct: $266,000
Dates: 7/1/08-6/30/11
Role: PI
Title: Genome wide association studies on conotruncal cardiac malformations (R01 resubmission)
Agency: NIH
Annual direct: $500,000
Dates: 7/1/08-6/30/13
Role: Co-investigator and subcontract PI
Brad A. Amendt (Principal Investigator)
NIH, 2 R01 DE013941-06, “Mechanisms of PITX2 Regulated Tooth Development”, 2/5/05-2/1/10, $1,250,000
P20/U54, NIDCR
Specialized Center for Dental Tissue Regeneration
The Chicago Blueprint for Dental Regeneration- part of a group to regenerate teeth using tissue engineering and progenitor cell technology. Phase I, $50,000.00, (3/01/06-2/28/07)
Pending funding:
NIH R21 0700838, "The Role of Islet-1 in Craniofacial Development", 12/1/07-11/30/09, $275,000
Past funding:
DHHS-NIH National Institute of Environmental Health Sciences; Center for Rural and Environmental Health. 0500749, Analysis of Forkhead Genes in Tooth Development, 4/1/05-3/31/06, $25,000
NIH, R01 DE13941, "Biochemical Analysis of Pitx2 and Tooth Development", 2/1/00-2/1/05, $933,765
American Heart Association, 9960299Z, "The Role of the Pitx2 Homeobox Protein In Heart Development", 7/1/99-6/30/01, $70,000
State/local
Past funding:
Mervin Bovaird Center for Molecular Biology and Biotechnology Faculty Grant, $26,000
PPARγ and cardiac metabolism, NIH RO1, Pending
