Jiang Chang, M.D., Ph.D.

Asisstant Professor, Center for Molecular Development and Disease

M.D. Wuhan University School of Medicine, Wuhan, China 

Ph.D., Texas A&M University, College Station, Texas; 

Postdoc, Baylor College of Medicine, Houston, Texas

 

Research

 Heart failure (impaired ventricular pump function) is an eventual outcome for diverse cardiovascular disorders and the leading cause of combined morbidity in the United States and other developed industrial nations.  The focus of my lab is to understand the molecular mechanisms that initiate and mediate the pathogenesis of heart failure.  The overall approach consists of using molecular and genetic engineering mouse models by generating constitutive and inducible transgenic mice as well as straight and conditional knockout mice with varied cardiomyopathies. 

 

 

Representative Publications

   

J. Chang, A.A. Knowlton and J.S. Wasser. Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance. American Journal of Physiology 278:R209-R214; 2000.

J. Chang, A.A. Knowlton, F. Xu and J.S. Wasser. Activation of the heat shock response: relationship to energy metabolites A 31P NMR study in rat hearts. American Journal of Physiology (Heart Circ Physiol) 280:H426-H433; 2001.

J. Chang, J.S. Wasser, R.N. Cornelussen and A.A. Knowlton. Activation of heat-shock factor by stretch-activated channels in rat hearts. Circulation 104:209-14; 2001.

J. Chang, L. Wei, T. Otani, K.A. Youker, M.L. Entman and R.J. Schwartz. Inhibitory cardiac transcription factor, SRF-N, is generated by caspase3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation 108:407-413; 2003.

J. Chang, M. Xie, V. Shah, M.D. Schneider, M.L. Entman, L. Wei and R.J. Schwartz. Activation of ROCK-1 by Caspase-3 Cleavage Plays an Essential Role in Cardiac Myocyte Apoptosis. Proc Natl Acad Sci USA 103:14495-500; 2006

V. R. Shah, M. I. Koster, D. R. Roop, D. M. Spencer, L. Wei, Q. Li, R. J. Schwartz and J Chang. Double-inducible gene activation system for caspase 3 and 9 in epidermis. Genesis 45:194-199, 2007.

 

Contact                                   

(713) 677-7603 (office)
(713) 677-7629 (lab 1)

 (713) 677-7615 (lab 2)

 (713) 677-7779 (Fax) 

Email: jchang@ibt.tamhsc.edu