R.D. Wells Symposium: DNA Structure, Mutagenesis, and Human Disease April 11, 2008
The seminar will be held in the second floor auditorium at
The Institute of Biosciences and Technology, The Texas A&M Health Science Center
2121 West Holcombe Boulevard, Houston TX 77030

For more information, contact Ms. Lorrie Adams at (713) 677-7652 or ladams@ibt.tamhsc.edu


PROGRAM


9:00 a.m. Dr. Magnus Hook, Welcome and Introductions

Session Chair: Dr. Hardy Chan, Chief Executive Officer, ScinoPharm Biotech, Ltd.; Co-founder and Chief Scientific Officer, ScinoPharm, Taiwan, Ltd.

9:05 a.m. Dr. Samuel H. Wilson, Acting Director, National Institute of Environmental Health Sciences, “Molecular Mechanisms of Mutagenesis During Base Excision Repair”

9:35 a.m. Dr. William R. Brinkley, V.P. Dean, Graduate School of Biomedical Sciences, Baylor College of Medicine, “Mitosis, Aneuploidy and Cancer: The Aurora Kinase Connection”

10:00 a.m. Dr. John H. Wilson, Biochemistry Dept., Baylor College of Medicine, “Triplet Repeats: Canaries in the Coal Mine”

10:30 a.m. Morning Break

Session Chair: Dr. Paul Schendel, Vice President, Project Management, Oncology, Hematology, Bone and Tissue Repair, Wyeth Pharmaceutical Company

10:50 a.m. Dr. James R. Lupski, Dept. of Molecular & Human Genetics, Baylor College of Medicine, "Molecular Mechanisms for Genomic Rearrangements Associated with Genomic Disorders"

11:20 a.m. Dr. Richard G. Brennan, Dept. of Biochemistry & Molecular Biology, U.T. M.D. Anderson Cancer Center, "Transcription Regulation through DNA Distortion"


12:00 p.m. Box lunches, 11th floor dining rooms


Session Chair: Dr. Jerry B. Dodgson, Michigan State University

1:30 p.m. Dr. Jack D. Griffith, University of North Carolina, Lineberger Cancer Center “T-loops and T-circles in the Replication of Telomers”

2:00 p.m. Dr. Sergei M. Mirkin, White Family Professor of Biology, Tufts University, "Mechanisms of Large-scale Repeat Expansions"

2:30 p.m. Dr. Tetsuo Ashizawa, John Sealy Chair of Neurology, U.T. Medical Branch "Expanded ATTCT Pentanucleotide Repeat in Spinocerebellar Ataxia Type 10."


3:00 p.m. Afternoon Break


Session Chair: Dr. William Reznikoff, University of Wisconsin-Madison & Woods Hole Marine Biological Labs

3:20 p.m. Dr. Joel M. Gottesfeld, Dept. of Molecular Biology, The Scripps Research Institute, “Gene Silencing in Friedreich’s Ataxia and Therapeutic Approaches”

3:50 p.m. Dr. Robert D. Wells, Institute of Biosciences and Technology, “What a Ride it’s Been: DNA Structure, Genomic Rearrangements and Human Disease”
*******
(c) 2005, Institute of Biosciences and Technology
                                      Health Science Center, Texas A&M University System